Wenxing Chen Selected Research

cryptotanshinone

1/2021	Cryptotanshinone Inhibits ERα-Dependent and -Independent BCRP Oligomer Formation to Reverse Multidrug Resistance in Breast Cancer.
1/2019	Correction to: Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells.
1/2017	Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells.
1/2017	Cryptotanshinone inhibition of mammalian target of rapamycin pathway is dependent on oestrogen receptor alpha in breast cancer.
10/2016	Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-α mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR.
9/2013	Molecular evidence of cryptotanshinone for treatment and prevention of human cancer.
5/2012	Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells.
8/2010	Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation.

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Wenxing Chen Research Topics

Disease

26	Neoplasms (Cancer) 01/2022 - 08/2010
12	Neoplasm Metastasis (Metastasis) 11/2019 - 01/2011
10	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2012
5	Melanoma (Melanoma, Malignant) 07/2018 - 01/2011
4	Carcinogenesis 02/2020 - 07/2014
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2013 - 01/2012
2	Hypoxia (Hypoxemia) 01/2022 - 01/2012
2	Pathologic Processes 11/2021 - 01/2020
2	Carcinoma (Carcinomatosis) 01/2021 - 07/2014
2	Body Weight (Weight, Body) 01/2020 - 01/2019
2	Chronic Hepatitis (Chronic Active Hepatitis) 01/2019 - 09/2013
2	Triple Negative Breast Neoplasms 01/2018 - 01/2015
2	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2011 - 03/2011
1	Poisoning 11/2021
1	Colonic Neoplasms (Colon Cancer) 01/2021
1	Skin Neoplasms (Skin Cancer) 07/2020
1	Colitis 01/2020
1	Granuloma 01/2020
1	Pharyngitis (Sore Throat) 01/2020
1	Colorectal Neoplasms (Colorectal Cancer) 11/2019
1	Hypercalcemia (Milk Alkali Syndrome) 11/2019
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2019
1	Inflammation (Inflammations) 01/2019
1	Leukemia 01/2019

Drug/Important Bio-Agent (IBA)

8	cryptotanshinoneIBA 01/2021 - 08/2010
5	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2021 - 08/2010
4	AntioxidantsIBA 01/2018 - 03/2011
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2015
3	EnzymesIBA 01/2018 - 07/2014
3	TOR Serine-Threonine KinasesIBA 01/2017 - 08/2010
3	GlycosaminoglycansIBA 12/2015 - 01/2013
3	IntegrinsIBA 12/2015 - 01/2012
3	Matrix Metalloproteinases (MMPs)IBA 12/2015 - 01/2013
2	tanshinoneIBA 01/2022 - 01/2021
2	MicroRNAs (MicroRNA)IBA 01/2022 - 02/2020
2	Pharmaceutical PreparationsIBA 01/2021 - 10/2019
2	Estrogen ReceptorsIBA 01/2021 - 01/2012
2	Estrogens (Estrogen)FDA Link 01/2021 - 01/2012
2	Acetates (Acetic Acid Esters)FDA Link 07/2020 - 07/2014
2	anthraceneIBA 07/2020 - 07/2014
2	LycopeneIBA 01/2020 - 07/2014
2	CarcinogensIBA 01/2020 - 07/2014
2	beta-elemeneIBA 10/2019 - 04/2011
2	elemeneIBA 10/2019 - 04/2011
2	Pyruvate KinaseIBA 10/2019 - 01/2019
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2019 - 01/2017
2	diallyl trisulfideIBA 01/2018 - 01/2015
2	Retinoblastoma ProteinIBA 01/2018 - 08/2010
2	Small Interfering RNA (siRNA)IBA 01/2018 - 01/2017
2	Cyclin D1IBA 01/2018 - 08/2010
2	Messenger RNA (mRNA)IBA 10/2016 - 01/2015
2	Angiogenesis InhibitorsIBA 10/2016 - 01/2011
2	Polysaccharides (Glycans)IBA 12/2015 - 01/2015
2	Volatile Oils (Essential Oils)IBA 06/2013 - 01/2011
2	CaspasesIBA 05/2012 - 11/2010
2	CadmiumIBA 04/2011 - 03/2011
1	lipid transfer protein (glycolipid transfer protein)IBA 01/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022
1	Oxygen (Dioxygen)IBA 01/2022
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/2021
1	ChlorineIBA 11/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	Dextran SulfateIBA 01/2020
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020
1	Therapeutic UsesIBA 01/2020
1	Lipocalin-2IBA 01/2020
1	Analgesics (Analgesic Drugs)IBA 01/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2020
1	CytokinesIBA 01/2020
1	purineIBA 01/2020
1	Uric Acid (Urate)IBA 01/2020
1	rheinIBA 01/2020
1	CalciumIBA 11/2019
1	Vitamin D FDA LinkGeneric 11/2019
1	Ion Channels (Ion Channel)IBA 11/2019
1	Dietary CalciumIBA 11/2019
1	18alpha,20beta- hydroxy- 11- oxo- norolean- 12- en- 3beta- yl- 2- O- beta- D- glucopyranurosyl- alpha- D- glucopyranosiduronate magnesium tetrahydrateIBA 01/2019
1	Alanine Transaminase (SGPT)IBA 01/2019
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2019
1	Cantharidin (Cantharides)IBA 01/2019
1	Cysteine (L-Cysteine)FDA Link 01/2019
1	Glycyrrhizic Acid (Glycyrrhizin)IBA 01/2019
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2019
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2019
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2018
1	isobavachalconeIBA 11/2018
1	Antineoplastic Agents (Antineoplastics)IBA 07/2018
1	ThioredoxinsIBA 01/2018
1	Indicators and Reagents (Reagents)IBA 01/2018
1	Oxidoreductases (Dehydrogenase)IBA 01/2018
1	chan su (ChanSu)IBA 01/2018
1	SolutionsIBA 01/2018
1	BufanolidesIBA 01/2018

Therapy/Procedure

13	Therapeutics 01/2022 - 01/2013
3	Chemoprevention 07/2020 - 10/2016
2	Drug Therapy (Chemotherapy) 01/2021 - 01/2021
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2019 - 09/2013
1	Immunotherapy 01/2021
1	Traditional Medicine (Folk Remedies) 07/2020
1	Intravenous Injections 01/2019